Invited Review ArticlePesticides and human chronic diseases: Evidences, mechanisms, and perspectives
Highlights
► There is a link between exposure to pesticides and incidence of chronic diseases. ► Genotoxicity and proteotoxicity are two main involved mechanisms. ► Epigenetic knowledge may help diagnose the relationships. ► Efficient policies on safe use of pesticides should be set up.
Introduction
Pesticides are considered as one of the main factors involved in environmental contamination of today's world. These chemicals are on purpose designed to be toxic to pest and vectors of diseases. These compounds are among more than 1000 active ingredients that are marketed as insecticide, herbicide, and fungicide. Nevertheless, formulation of new and potent pesticides is increasingly on the order of researchers and manufacturers because of pest resistance, hygienic controls, and major human need for more food as the world population grows. Although pesticides have largely benefited the human life through enhancement of agricultural products and controlling infectious diseases, their extensive use, in turn, has offended human health from side to side of occupational or environmental exposures. Long-term contact to pesticides can harm human life and can disturb the function of different organs in the body, including nervous, endocrine, immune, reproductive, renal, cardiovascular, and respiratory systems. In this regard, there is mounting evidence on the link of pesticide's exposure with the incidence of human chronic diseases, including cancer, Parkinson, Alzheimer, multiple sclerosis, diabetes, aging, cardiovascular and chronic kidney disease (Abdollahi et al., 2004c, De Souza et al., 2011, Mostafalou and Abdollahi, 2012a). In this overview, we discuss the association of pesticide's exposure with the incidence of different types of human chronic diseases as well as general mechanisms of disease's process, which can be involved in pesticide-induced toxicities.
Section snippets
Evidences for the link between pesticide exposure and incidence of chronic diseases
Chronic diseases are characterized by their generally slow progression and long term duration, which are considered as the leading cause of mortality in the new world, representing over 60% of all deaths. According to the WHO report, 36 million people died from chronic disease in 2008, of which nine million were under 60 and 90% of these premature deaths occurred in low- and middle-income countries (http://www.who.int/topics/chronic_diseases/en/).
Genetic damages
Genetic damages are caused by direct interaction with genetic material resulting in DNA damage or chromosomal aberrations and considered as a primary mechanism for chronic diseases within the context of carcinogenesis and teratogenesis. They are studied in the field of genetic toxicology and can be detected by distinctive kinds of genotoxicity tests. Growing body of data concerning genetic toxicity of pesticides have been collected from epidemiological and experimental studies using different
Endocrine disruption
At a cellular level, endocrine disruption refers to a mechanism of toxicity that interferes the ability of the cells to communicate hormonally and results in a wide variety of adverse health effects including birth defects, reproductive, developmental, metabolic, immune, and neurobehavioral disorders as well as hormone dependent cancers. The term “endocrine disruptor” (ED) was first introduced in 1991 referring to the substances that interfere with synthesis, secretion, transport, binding,
Conclusion
Taken together, chronic diseases discussed above are considered as the major disorders affecting public health in the 21st century. The relationship between these diseases and environmental exposures, particularly pesticides increasingly continues to strengthen. Near to all studies carried out in the area of pesticides, and chronic diseases are categorized in the field of epidemiologic evidence or experimental investigation with mechanistic insight into the disease process. Some epidemiologic
Conflict of interest statement
There is no competing interest.
Acknowledgments
Authors wish to thank assistances of INSF and TUMS.
References (476)
- et al.
Hyperglycemia associated with increased hepatic glycogen phosphorylase and phosphoenolpyruvate carboxykinase in rats following subchronic exposure to malathion
Comp. Biochem. Physiol. C Toxicol. Pharmacol.
(2004) - et al.
Oxidative stress and cholinesterase inhibition in saliva and plasma of rats following subchronic exposure to malathion
Comp. Biochem. Physiol. C. Toxicol. Pharmacol.
(2004) - et al.
Risk of pancreatic cancer and occupational exposures in Spain. PANKRAS II Study Group
Ann. Occup. Hyg.
(2000) - et al.
Modulation of antioxidant defense systems by the environmental pesticide maneb in dopaminergic cells
Neurotoxicology
(2005) - et al.
Augmentation of hepatic and renal oxidative stress and disrupted glucose homeostasis by monocrotophos in streptozotocin-induced diabetic rats
Chem. Biol. Interact.
(2011) Genotoxicity of pesticides: a review of human biomonitoring studies
Mutat. Res.
(2003)- et al.
Maternal pesticide exposure and neural tube defects in Mexican Americans
Ann. Epidemiol.
(2010) - et al.
TP53 gene mutations of lung cancer patients in upper northern Thailand and environmental risk factors
Cancer Genet. Cytogenet.
(2008) - et al.
Perinatal heptachlor exposure increases expression of presynaptic dopaminergic markers in mouse striatum
Neurotoxicology
(2005) - et al.
GSK3beta and endoplasmic reticulum stress mediate rotenone-induced death of SK-N-MC neuroblastoma cells
Biochem. Pharmacol.
(2008)
Pyrrolidine dithiocarbamate (PDTC)/Cu complex induces lung epithelial cell apoptosis through mitochondria and ER-stress pathways
Toxicol. Lett.
Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma
Blood
Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome
J. Biol. Chem.
Mechanisms of rotenone-induced proteasome inhibition
Neurotoxicology
Myeloid leukemias and myelodysplastic syndromes: chemical exposure, histologic subtype and cytogenetics in a case–control study
Cancer Genet. Cytogenet.
Morphologic, immunologic and cytogenetic studies in acute myeloid leukemia following occupational exposure to pesticides and organic solvents
Leuk. Res.
Cytogenetic biomonitoring of an Italian population exposed to pesticides: chromosome aberration and sister-chromatid exchange analysis in peripheral blood lymphocytes
Mutat. Res.
Pesticides and oxidative stress: a review
Med. Sci. Monit.
Mitochondrial dysfunction, insulin resistance, and type 2 diabetes mellitus
Curr. Diab. Rep.
Studies on lipid peroxidation and non-enzymatic antioxidant status as indices of oxidative stress in patients with chronic myeloid leukaemia
Singapore Med. J.
Occupational pesticide exposures and cancer risk: a review
J. Toxicol. Environ. Health B Crit. Rev.
Cancer mortality in the U.S. flour industry
J. Natl. Cancer Inst.
Use of agricultural pesticides and prostate cancer risk in the Agricultural Health Study cohort
Am. J. Epidemiol.
Pesticides and lung cancer risk in the agricultural health study cohort
Am. J. Epidemiol.
Child and maternal household chemical exposure and the risk of acute leukemia in children with Down's syndrome: a report from the Children's Oncology Group
Am. J. Epidemiol.
Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion
Cancer Res.
Agricultural pesticide use and pancreatic cancer risk in the Agricultural Health Study Cohort
Int. J. Cancer
Effect of the pesticide, fundazol, on the myocardium of rats with experimental atherosclerosis
Probl. Khig.
Epigenetic transgenerational actions of endocrine disruptors
Endocrinology
Epigenetic transgenerational actions of endocrine disruptors and male fertility
Science
Mucociliary transport in patients with chronic obstructive lung disease from the cotton-growing areas of Uzbekistan
Probl. Tuberk. Bolezn. Legk.
Pesticide exposure and risk for Parkinson's disease
Ann. Neurol.
Endoplasmic reticulum stress in the beta-cell pathogenesis of type 2 diabetes
Exp. Diabetes Res.
Cancers and pesticides
Rev. Prat.
Association between Parkinson's disease and exposure to pesticides in southwestern France
Neuroepidemiology
Neurodegenerative diseases and exposure to pesticides in the elderly
Am. J. Epidemiol.
Identification of occupational cancer risks in British Columbia. A population-based case–control study of 995 incident breast cancer cases by menopausal status, controlling for confounding factors
J. Occup. Environ. Med.
Prostate cancer risk and exposure to pesticides in British Columbia farmers
Prostate
Ecogenetics of Parkinson's disease: prevalence and environmental aspects in rural areas
Can. J. Neurol. Sci.
The influence of occupational exposure to pesticides on the frequency of chronic obstructive pulmonary diseases
Wiad. Lek.
A fetal risk factor for Parkinson's disease
Dev. Neurosci.
Increased risk of lung cancer in pesticide-exposed male agricultural workers
J. Toxicol. Environ. Health
Cancer incidence among male pesticide applicators in the Agricultural Health Study cohort exposed to diazinon
Am. J. Epidemiol.
Health impacts of pesticide exposure in a cohort of outdoor workers
Environ. Health Perspect.
Chronic fatigue syndrome: a possible delayed hazard of pesticide exposure
Clin. Infect. Dis.
Glyphosate formulations induce apoptosis and necrosis in human umbilical, embryonic, and placental cells
Chem. Res. Toxicol.
Lung cancer and other causes of death among licensed pesticide applicators
J. Natl. Cancer Inst.
Frequency of micronuclei in lymphocytes from a group of floriculturists exposed to pesticides
J. Toxicol. Environ. Health
Pesticide–Parkinson link explored
Nat. Med.
Occupational exposure to terbufos and the incidence of cancer in the Agricultural Health Study
Cancer Causes Control
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